Det er blevet rygtet en række gange, at Naughty Dog arbejder på en efterfølger til The Last of Us, og har gjort det i noget tid. Men produceren Neil Druckmann siger dog nu, at dette ikke er sandt, selvom han er hurtig til at indrømme, at udvikleren har brainstormet en masse ideer. En af disse, er helt nye karakterer:
"We were brainstorming ideas for The Last Of Us 2 with new characters; ideas for Joel and Ellie; ideas for a sci-fi game; ideas for a fantasy game, and building prototypes for each one of those ideas. So, I guess Nolan North was kind of right in that we were working on stuff, but we don't know what we're doing next and we won't know until probably a few months after we finish Uncharted 4."
Tak Official PlayStation Magazine (via Games Radar