Deus Ex: Mankind Divided har ingen multiplayer-del. Det har spillets gameplay-instruktør Patrick Fortier bekræftet i et interview med GamesRadar, og pointerer i denne forbindelse, at multiplayer-suiter alt for ofte klistres unødigt med i spil, som slet ikke har brug for det. Hvis multiplayer dog en dag skulle snige sig ind i Deus Ex-serien, så bliver det i en form som er naturligt for spillet:
"If we were to go in that direction it would have to be the topic of the game itself,"
"I don't think it's something that can be tacked on and supported sufficiently well through a third party developer, out of the office. It has to be fundamental right from day one that you're trying to do that. You have to have the right idea and the right vehicle."
Et lysende eksempel på velintegreret multiplayer i et RPG, er Mass Effect 3 ifølge Fortier:
"Mass effect 3's multiplayer is a very good experience. It's proof that it can be done. I'm not saying that we can't do it, but you know [BioWare is] in the fourth iteration [of its game] now, almost, whereas we're only on the second of ours. There's a lot of learning we need to go through! In the future, I think if we were to go in that direction it would have to be the topic of the game itself. The way we're applying the formula, in the sense of the narrative component [impacting] all across the different disciplines, I think it would have to be that it makes sense story-wise."
Deus Ex: Mankind Divided er kun single-player, og udkommer på PS4, Xbox One og PC i starten af 2016.
