Der har længe været rygter om, at nu hvor Naughty Dog vinker farvel til Uncharted-serien for nu med Uncharted 4: A Thief's End, vil det også være enden på hovedpersonen Nathan Drake. Neil Druckmann, spillets instruktør, udtaler sig således om spillet i et interview med The Sun:
"He's at the height of his popularity, so it's not a good business decision. But I feel like the best way to honour him is to go out on top, to finish his story.
"Whether that's it for Uncharted? I don't know. At the end of the day Sony owns Uncharted and they can do whatever they want"
Dog siger Druckmann afslutningsvis:
"But with the end of this story, it will be really hard to do a sequel with Nathan Drake."
Hvad tror du?