Spider-Man markerer starten på et fornyet fokus på spilbranchen for Marvel, og nu hvor de har haft så gigantisk succes med at sammenbinde deres diverse film til ét samlet univers kaldet Marvel Cinematic Universe, kunne man så forestille sig at Spider-Man kunne lede til et Marvel Game Universe?
Netop dette har Telegraph talt med Marvels spilchef Bill Rosemann om, og selvom han ikke afslører noget konkret, så fortæller han at der er flere "individual games", som meget vel kunne krydse over med hinanden.
"There was. I mean, they tacked on that Nick Fury scene at the end of Iron Man but did anyone think it would culminate in The Avengers? Or now Avengers Infinity War? That was a pipe dream. The first intention was, let's just make the best Iron Man movie. We're approaching it the same way. This is going to be hard enough. Let's just make the best Spider-Man game. Let's do that. The rest will take care of itself. Who knows what the future holds? We just want to make sure each individual game is awesome, is great. Again we don't want to trap people and contain people. We want to give them freedom."
Desuden indeholder byen i spillet en række referencer til andre karakterer i universet, andre helte, deriblandt The Avengers, og sådan et projekt arbejder Square Enix på, og da Rosemann blev spurgt om hvorvidt disse to spil hænger sammen svarede han:
"Again, I don't want to talk about that now. We just want to focus on Marvel Spider-Man. Um. But I will say... we're all Marvel fans!"