Activision og Red Octane har offentliggjort 11 nye numre som kommer med I Guitar Hero III som udkommer til efteråret. De første syv numre på listen er indspillet af den originale kunstner, mens de sidste fire er coverversioner.
Miss Murder (by AFI)
Through Fire and Flames (by Dragonforce)
Number of the Beast (by Iron Maiden)
3's and 7's (by Queens of the Stone Age)
Suck My Kiss (by Red Hot Chili Peppers)
Raining Blood (by Slayer)
Reptillia (by The Strokes)
Paranoid (as made famous by Black Sabbath)
Cities on Flame (as made famous by Blue Oyster Cult)
Mississippi Queen (as made famous by Mountain)
La Grange (as made famous by ZZ Top)
Tidligere er følgende sange bekræftet:
Slash's Original Boss Battle Recording
Welcome to The Jungle (by Guns N' Roses)
Paint It Black (by The Rolling Stones)
Cherub Rock (by Smashing Pumpkins)
Sabotage (by Beastie Boys)
The Metal (by Tenacious D)
My Name is Jonas (by Weezer)
Knights of Cydonia (by Muse)
Even Flow (by Pearl Jam)
Lay Down (by Priestess)
Cult of Personality (by Living Colour)
Rock and Roll All Nite (as made famous by Kiss)
School's Out (as made famous by Alice Cooper)
Rock You Like a Hurricane (as made famous by Scorpions)
Slow Ride (as made famous by Foghat)
Barracuda (as made famous by Heart)